Body Composition and Metabolomics in the Alberta Physical Activity and Breast Cancer Prevention Trial.

Our results demonstrate how a thorough evaluation of the components of fat and lean mass, along with BMI provides a more accurate assessment of the associations between body composition and metabolites than BMI alone. Such an assessment makes evident that some metabolites correlated with BMI predominantly reflect lean mass rather than fat, and some metabolites related to body composition are not correlated with BMI. Correctly characterizing these relationships is important for accurate understanding of how and why obesity is associated with disease.