IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes.
Abigail C LayLorna J HaleHolly Stowell-ConnollyRobert J P PopeViji NairWenjun JuEva MarquezRuth RollasonJennifer A HurcombeBryony HayesTimothy RobertsLawrence GillamJonathan AllingtonRobert G NelsonMatthias KretzlerJeff M P HollyClaire M PerksCraig A McArdleGavin I WelshRichard J M CowardPublished in: Diabetologia (2021)
This work identifies a novel role for IGFBP-1 in the regulation of podocyte function and that the glomerular expression of IGFBP-1 is reduced in the early stages of type 2 DKD, via reduced FoxO1 activity. Thus, we hypothesise that strategies to maintain glomerular IGFBP-1 levels may be beneficial in maintaining podocyte function early in DKD.