SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients.
Eric N Jimenez-VazquezMichael AradAlvaro MaciasMaria L Vera-PedrosaFrancisco Miguel CruzLilian K GutierrezAshley J CuttittaAndre Monteiro da RochaTodd J HerronDaniela Ponce-BalbuenaGuadalupe Guerrero-SernaOfer BinahDaniel E MicheleJose JalifePublished in: eLife (2022)
2020 (LA MARATO-2020); Instituto de Salud Carlos III/FEDER/FSE; Horizon 2020 - Research and Innovation Framework Programme GA-965286 to JJ; the CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation), and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). American Heart Association postdoctoral fellowship 19POST34380706s to JVEN. Israel Science Foundation to OB and MA [824/19]. Rappaport grant [01012020RI]; and Niedersachsen Foundation [ZN3452] to OB; US-Israel Binational Science Foundation (BSF) to OB and TH [2019039]; Dr. Bernard Lublin Donation to OB; and The Duchenne Parent Project Netherlands (DPPNL 2029771) to OB. National Institutes of Health R01 AR068428 to DM and US-Israel Binational Science Foundation Grant [2013032] to DM and OB.
Keyphrases
- muscular dystrophy
- public health
- end stage renal disease
- induced pluripotent stem cells
- healthcare
- quality improvement
- ejection fraction
- chronic kidney disease
- newly diagnosed
- heart failure
- peritoneal dialysis
- pet ct
- gene expression
- randomized controlled trial
- type diabetes
- mouse model
- prognostic factors
- adipose tissue
- metabolic syndrome
- skeletal muscle
- patient reported outcomes
- copy number
- dna methylation
- health information
- anti inflammatory
- insulin resistance
- human health
- double blind
- glycemic control