Cancer-associated Fibroblast-specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis.
James HutchenreutherJohn NguyenKatherine QuesnelKrista Marie VincentLouis PetitjeanSophia BourgeoisMark BoydGeorge Bou-GhariosLynne-Marie PostovitAndrew LeaskPublished in: Cancer research communications (2024)
In human patients, the expression of proangiogenic matricellular protein CCN1 in CAFs correlates positively with expression of stroma and angiogenic markers and progressive disease/resistance to checkpoint inhibitor therapy. In an animal model, loss of CCN1 from CAFs impaired metastasis of melanoma cells, neovascularization, and collagen deposition, emphasizing that CAFs coordinate cellular behavior in a tumor microenvironment and that CCN1 may be a novel target.
Keyphrases
- endothelial cells
- vascular endothelial growth factor
- poor prognosis
- binding protein
- end stage renal disease
- multiple sclerosis
- chronic kidney disease
- ejection fraction
- dna damage
- long non coding rna
- protein protein
- stem cells
- prognostic factors
- cell cycle
- amino acid
- patient reported outcomes
- patient reported
- pluripotent stem cells