Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cells.
F CoperchiniA GrecoM DenegriF A RipepiB GrilliniJ BertiniB CalìL VillaniF MagriL CroceC GaetanoC CappelliP TrimboliL ChiovatoMario RotondiPublished in: Journal of endocrinological investigation (2022)
VitD would defend the body by SARS-COV2 both by regulating the host immune defense and by up-regulating of the expression of the ACE-2 receptor. The existence of a co-operation between VitD and IFN-γ demonstrated in other systems is supported also for ACE-2 up-regulation. These observations lead to an increased interest for the potential therapeutic benefits of VitD supplementation in COVID-19.
Keyphrases
- sars cov
- angiotensin converting enzyme
- angiotensin ii
- induced apoptosis
- dendritic cells
- endothelial cells
- coronavirus disease
- respiratory syndrome coronavirus
- poor prognosis
- cell cycle arrest
- binding protein
- immune response
- induced pluripotent stem cells
- endoplasmic reticulum stress
- pluripotent stem cells
- cell proliferation