Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity.
Christian SchwedlerThomas HäuplUlrich KalusVéronique BlanchardGerd-Rüdiger BurmesterDenis PoddubnyyBerthold HoppePublished in: Arthritis research & therapy (2018)
Increased IgG hypogalactosylation in RA but not in axSpA points to humoral immune response as a precondition. Reduced B4GALT3 expression in B cells compared with plasma cells supports relatedness to early B-cell triggering. The differential influence of RA treatment on IgG hypogalactosylation renders it a potential diagnostic target for further studies.
Keyphrases
- rheumatoid arthritis
- immune response
- disease activity
- induced apoptosis
- ankylosing spondylitis
- rheumatoid arthritis patients
- poor prognosis
- interstitial lung disease
- cell cycle arrest
- binding protein
- systemic lupus erythematosus
- dendritic cells
- toll like receptor
- cell death
- protein protein
- cell proliferation
- amino acid
- human health
- systemic sclerosis
- signaling pathway
- pi k akt
- idiopathic pulmonary fibrosis