PPARγ is reduced in the airways of non-CF bronchiectasis subjects and is inversely correlated with the presence of Pseudomonas aeruginosa.
Lucy D BurrGeraint B RogersAlice C-H ChenSteven L TaylorSimon D BowlerRebecca L KeatingMegan L MartinSumaira Z HasnainMichael A McGuckinPublished in: PloS one (2018)
PPARγ is expressed in low levels in the airways of non-CF bronchiectasis subjects, despite an aggressive inflammatory response. This low level PPARγ expression is particularly associated with the presence of high levels of P. aeruginosa, and may represent an intrinsic link with this bacterial pathogen.