Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress.
Stefanie RenkenTakahiro NakajimaIsabelle MagalhaesJonas MattssonAndreas LundqvistElias S J ArnérRolf KiesslingStina Linnea WickströmPublished in: Journal for immunotherapy of cancer (2022)
These novel findings suggest that Nrf2 activation in human cytotoxic lymphocytes could be used to enhance the efficacy of adoptive cell therapy.