Elias S J Arnér (E S J Arnér, Elias Sj Arnér)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 30

Top Venues

The EMBO journal

Journal of the American Chemical Society

Science advances

Nature communications

Karolinska Institutet

Karolinska Institutet (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Karolinska Institutet Mar 01 2009

Sweden

Professor :: Medical Biochemistry and Biophysics, Division of Biochemistry

Education History

Karolinska Institutet

Sweden

PHD

Publications

Pablo Martí-Andrés, Isabela Finamor, Isabel Torres-Cuevas, Salvador Pérez, Sergio Rius-Pérez, Hildegard Colino-Lage, David Guerrero-Gómez, Esperanza Morato, Anabel Marina, Patrycja Michalska, Rafael León, Qing Cheng, Eszter Petra Jurányi, Klaudia Borbényi-Galambos, Iván Millán, Péter Nagy, Antonio Miranda-Vizuete, Edward E Schmidt, Antonio Martínez-Ruiz, Elias S J Arnér, Juan Sastre
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. The EMBO journal 43 (13) (2024)
Lukas Zeisel, Jan G Felber, Karoline C Scholzen, Carina Schmitt, Alexander J Wiegand, Leonid Komissarov, Elias S J Arnér, Oliver Thorn-Seshold
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology. Journal of the American Chemical Society 146 (8) (2024)
Lukas Zeisel, Jan G Felber, Karoline C Scholzen, Carina Schmitt, Alexander J Wiegand, Leonid Komissarov, Elias S J Arnér, Oliver Thorn-Seshold
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology. Journal of the American Chemical Society 146 (8) (2024)
Pablo Martí-Andrés, Isabela Finamor, Isabel Torres-Cuevas, Salvador Pérez, Sergio Rius-Pérez, Hildegard Colino-Lage, David Guerrero-Gómez, Esperanza Morato, Anabel Marina, Patrycja Michalska, Rafael León, Qing Cheng, Eszter Petra Jurányi, Klaudia Borbényi-Galambos, Iván Millán, Péter Nagy, Antonio Miranda-Vizuete, Edward E Schmidt, Antonio Martínez-Ruiz, Elias S J Arnér, Juan Sastre
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. The EMBO journal (2024)
Pablo Martí-Andrés, Isabela Finamor, Isabel Torres-Cuevas, Salvador Pérez, Sergio Rius-Pérez, Hildegard Colino-Lage, David Guerrero-Gómez, Esperanza Morato, Anabel Marina, Patrycja Michalska, Rafael León, Qing Cheng, Eszter Petra Jurányi, Klaudia Borbényi-Galambos, Iván Millán, Péter Nagy, Antonio Miranda-Vizuete, Edward E Schmidt, Antonio Martínez-Ruiz, Elias S J Arnér, Juan Sastre
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. The EMBO journal 43 (13) (2024)
Pablo Martí-Andrés, Isabela Finamor, Isabel Torres-Cuevas, Salvador Pérez, Sergio Rius-Pérez, Hildegard Colino-Lage, David Guerrero-Gómez, Esperanza Morato, Anabel Marina, Patrycja Michalska, Rafael León, Qing Cheng, Eszter Petra Jurányi, Klaudia Borbényi-Galambos, Iván Millán, Péter Nagy, Antonio Miranda-Vizuete, Edward E Schmidt, Antonio Martínez-Ruiz, Elias S J Arnér, Juan Sastre
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. The EMBO journal 43 (13) (2024)
Pablo Martí-Andrés, Isabela Finamor, Isabel Torres-Cuevas, Salvador Pérez, Sergio Rius-Pérez, Hildegard Colino-Lage, David Guerrero-Gómez, Esperanza Morato, Anabel Marina, Patrycja Michalska, Rafael León, Qing Cheng, Eszter Petra Jurányi, Klaudia Borbényi-Galambos, Iván Millán, Péter Nagy, Antonio Miranda-Vizuete, Edward E Schmidt, Antonio Martínez-Ruiz, Elias S J Arnér, Juan Sastre
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. The EMBO journal 43 (13) (2024)
Lukas Zeisel, Jan G Felber, Karoline C Scholzen, Carina Schmitt, Alexander J Wiegand, Leonid Komissarov, Elias S J Arnér, Oliver Thorn-Seshold
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology. Journal of the American Chemical Society 146 (8) (2024)
Lukas Zeisel, Jan G Felber, Karoline C Scholzen, Carina Schmitt, Alexander J Wiegand, Leonid Komissarov, Elias S J Arnér, Oliver Thorn-Seshold
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology. Journal of the American Chemical Society (2024)
Pablo Martí-Andrés, Isabela Finamor, Isabel Torres-Cuevas, Salvador Pérez, Sergio Rius-Pérez, Hildegard Colino-Lage, David Guerrero-Gómez, Esperanza Morato, Anabel Marina, Patrycja Michalska, Rafael León, Qing Cheng, Eszter Petra Jurányi, Klaudia Borbényi-Galambos, Iván Millán, Péter Nagy, Antonio Miranda-Vizuete, Edward E Schmidt, Antonio Martínez-Ruiz, Elias S J Arnér, Juan Sastre
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. The EMBO journal 43 (13) (2024)
Stefanie Renken, Takahiro Nakajima, Isabelle Magalhaes, Jonas Mattsson, Andreas Lundqvist, Elias S J Arnér, Rolf Kiessling, Stina Linnea Wickström
Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress. Journal for immunotherapy of cancer 10 (6) (2022)
Jan G Felber, Lena Poczka, Karoline C Scholzen, Lukas Zeisel, Martin S Maier, Sander Busker, Ulrike Theisen, Christina Brandstädter, Katja Becker, Elias S J Arnér, Julia Ahlfeld, Oliver Thorn-Seshold
Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically. Nature communications 13 (1) (2022)
Faruq Mohammed Hossain, Yana Bodnar, Calvin Klein, Clara Ortegón Salas, Elias S J Arnér, Manuela Gellert, Christopher Horst Lillig
Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases. Oxidative medicine and cellular longevity 2021 (2021)
Éva Dóka, Elias S J Arnér, Edward E Schmidt, Tobias P Dick, Albert van der Vliet, Jing Yang, Réka Szatmári, Tamás Ditrói, John L Wallace, Giuseppe Cirino, Kenneth R Olson, Hozumi Motohashi, Jon M Fukuto, Michael D Pluth, Martin Feelisch, Takaaki Akaike, David A Wink, Louis J Ignarro, Peter Nagy
Comment on "Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity". Science advances 7 (17) (2021)
Markus Dagnell, Qing Cheng, Elias S J Arnér
Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate. Antioxidants (Basel, Switzerland) 10 (1) (2021)
Jan G Felber, Lukas Zeisel, Lena Poczka, Karoline Scholzen, Sander Busker, Martin S Maier, Ulrike Theisen, Christina Brandstädter, Katja Becker, Elias S J Arnér, Julia Ahlfeld, Oliver Thorn-Seshold
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif. Journal of the American Chemical Society 143 (23) (2021)
Amir Ata Saei, Christian Michel Beusch, Pierre Sabatier, Juan Astorga Wells, Hassan Gharibi, Zhaowei Meng, Alexey L Chernobrovkin, Sergey Rodin, Katja Näreoja, Ann-Gerd Thorsell, Tobias Karlberg, Qing Cheng, Susanna L Lundström, Massimiliano Gaetani, Ákos Végvári, Elias S J Arnér, Herwig Schüler, Roman A Zubarev
System-wide identification and prioritization of enzyme substrates by thermal analysis. Nature communications 12 (1) (2021)
Éva Dóka, Tomoaki Ida, M Dagnell, Y Abiko, Nho Cong Luong, N Balog, Tsuyoshi Takata, B Espinosa, A Nishimura, Qing Cheng, Y Funato, H Miki, J M Fukuto, J R Prigge, E E Schmidt, Elias S J Arnér, Yoshito Kumagai, Takaaki Akaike, Peter Nagy
Control of protein function through oxidation and reduction of persulfidated states. Science advances 6 (1) (2020)
Haining Lyu, Pavel A Petukhov, Paul R Banta, Ajit Jadhav, Wendy A Lea, Qing Cheng, Elias S J Arnér, Anton Simeonov, Gregory R J Thatcher, Francesco Angelucci, David L Williams
Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS infectious diseases 6 (3) (2020)
Ingrid J Pickering, Qing Cheng, Emérita Mendoza Rengifo, Susan Nehzati, Natalia V Dolgova, Thomas Kroll, Dimosthenis Sokaras, Graham N George, Elias S J Arnér
Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase. Inorganic chemistry 59 (5) (2020)
Sander Busker, W Qian, M Haraldsson, B Espinosa, L Johansson, S Attarha, I Kolosenko, J Liu, M Dagnell, D Grandér, Elias S J Arnér, Katja Pokrovskaja Tamm, Brent D G Page
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death. Science advances 6 (12) (2020)
William C Stafford, Xiaoxiao Peng, Maria Hägg Olofsson, Xiaonan Zhang, Diane K Luci, Li Lu, Qing Cheng, Lionel Trésaugues, Thomas S Dexheimer, Nathan P Coussens, Martin Augsten, Hanna-Stina Martinsson Ahlzén, Owe Orwar, Arne Östman, Sharon Stone-Elander, David J Maloney, Ajit Jadhav, Anton Simeonov, Stig Linder, Elias S J Arnér
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Science translational medicine 10 (428) (2019)
Yurika Katsu-Jiménez, Carmela Vázquez-Calvo, Camilla Maffezzini, Maria Halldin, Xiaoxiao Peng, Christoph Freyer, Anna Wredenberg, Alfredo Giménez-Cassina, Anna Wedell, Elias S J Arnér
Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate. Diabetes 68 (4) (2019)
Michael R McLoughlin, David J Orlicky, Justin R Prigge, Pushya Krishna, Emily A Talago, Ian R Cavigli, Sofi Eriksson, Colin G Miller, Jean A Kundert, Volkan I Sayin, Rachel A Sabol, Joshua Heinemann, Luke O Brandenberger, Sonya V Iverson, Brian Bothner, Thales Papagiannakopoulos, Colin T Shearn, Elias S J Arnér, Edward E Schmidt
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy. Proceedings of the National Academy of Sciences of the United States of America 116 (23) (2019)
Karthik Selvaraju, Arjan Mofers, Paola Pellegrini, Johannes Salomonsson, Alexandra Ahlner, Vivian Morad, Ellin-Kristina Hillert, Belen Espinosa, Elias S J Arnér, Lasse Jensen, Jonas Malmström, Maria V Turkina, Padraig D'Arcy, Michael A Walters, Maria Sunnerhagen, Stig Linder
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system. Scientific reports 9 (1) (2019)
Karthik Selvaraju, Arjan Mofers, Paola Pellegrini, Johannes Salomonsson, Alexandra Ahlner, Vivian Morad, Ellin-Kristina Hillert, Belen Espinosa, Elias S J Arnér, Lasse Jensen, Jonas Malmström, Maria V Turkina, Padraig D'Arcy, Michael A Walters, Maria Sunnerhagen, Stig Linder
Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system. Scientific reports 9 (1) (2019)
Ilaria Silvestri, Haining Lyu, Francesca Fata, Giovanna Boumis, Adriana E Miele, Matteo Ardini, Rodolfo Ippoliti, Andrea Bellelli, Ajit Jadhav, Wendy A Lea, Anton Simeonov, Qing Cheng, Elias S J Arnér, Gregory R J Thatcher, Pavel A Petukhov, David L Williams, Francesco Angelucci
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS chemical biology 13 (8) (2018)
Belén Espinosa, Elias S J Arnér
Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways. British journal of pharmacology 176 (4) (2018)
Greg J Poet, Ojore Bv Oka, Marcel van Lith, Zhenbo Cao, Philip J Robinson, Marie Anne Pringle, Elias S J Arnér, Neil John Bulleid
Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER. The EMBO journal 36 (5) (2017)
Éva Dóka, Irina Pader, Adrienn Bíró, Katarina Johansson, Qing Cheng, Krisztina Ballagó, Justin R Prigge, Daniel Pastor-Flores, Tobias P Dick, Edward E Schmidt, Elias S J Arnér, Péter Nagy
A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems. Science advances 2 (1) (2016)
Y Shi, F Nikulenkov, J Zawacka-Pankau, H Li, R Gabdoulline, J Xu, S Eriksson, E Hedström, N Issaeva, A Kel, Elias S J Arnér, G Selivanova
ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis. Cell death and differentiation 21 (4) (2014)
X Peng, P K Mandal, V O Kaminskyy, A Lindqvist, M Conrad, Elias S J Arnér
Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2. Cell death & disease 5 (2014)

Elias S J Arnér.css-eqlu8i{font-size:small;padding-left:4px;} (E S J Arnér, Elias Sj Arnér)

Publication Activity (10 Years)

Top Topics

Top Venues

Elias S J Arnér (E S J Arnér, Elias Sj Arnér)