Deep Sedation in Traumatic Brain Injury Patients.
Yoon-Hee ChooYoungbeom SeoSeok-Mann YoonPublished in: Korean journal of neurotrauma (2023)
Traumatic brain injury (TBI) is one of the leading causes of mortality and disability in adults. In cases of severe TBI, preventing secondary brain injury by managing intracranial hypertension during the acute phase is a critical treatment challenge. Among surgical and medical interventions to control intracranial pressure (ICP), deep sedation can provide comfort to patients and directly control ICP by regulating cerebral metabolism. However, insufficient sedation does not achieve the intended treatment goals, and excessive sedation can lead to fatal sedative-related complications. Therefore, it is important to continuously monitor and titrate sedatives by measuring the appropriate depth of sedation. In this review, we discuss the effectiveness of deep sedation, techniques to monitor the depth of sedation, and the clinical use of recommended sedatives, barbiturates, and propofol in TBI.
Keyphrases
- traumatic brain injury
- mechanical ventilation
- end stage renal disease
- ejection fraction
- newly diagnosed
- healthcare
- prognostic factors
- severe traumatic brain injury
- randomized controlled trial
- systematic review
- blood pressure
- type diabetes
- physical activity
- subarachnoid hemorrhage
- intensive care unit
- patient reported outcomes
- public health
- brain injury
- cerebral ischemia
- global health