Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells.

Yan LiYong LiuKailong WangYinghui HuangWenhao HanJiachuan XiongKe YangMingying LiuTangli XiaoChi LiuTing HeXianjin BiJingbo ZhangBo ZhangJinghong Zhao

Published in: BMC molecular and cell biology (2020)

These data demonstrate that KL is a transcriptional target of Sp1 and TGF-β1-induced fibrosis was alleviated by Sp1 in human RTECs by directly modulating Klotho expression, which help to further understand the transcriptional regulation of Klotho in renal disease models.

Keyphrases

transcription factor
high glucose
endothelial cells
poor prognosis
gene expression
signaling pathway
transforming growth factor
big data
induced pluripotent stem cells
long non coding rna
pluripotent stem cells
drug induced
dna binding
deep learning
heat shock
heat stress