Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup.
Christine PirkerAgnes BileczMichael GruschThomas MohrBarbara HeidenreichViktoria LaszloPaul StockhammerDaniela Lötsch-GojoJohannes GojoLisa GablerSabine Spiegl-KreineckerBalazs DomeAriane SteindlThomas KlikovitsMir Alireza HodaMarko JakopovicMiroslav SamarzijaKatja MohorcicIzidor KernBarbara KieselLuka BrcicFelicitas OberndorferLeonhard MüllauerWalter KlepetkoWolfgang M SchmidtRajiv KumarBalazs HegedüsWalter BergerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
TERT promoter mutations independently predict a dismal course of disease in human MPM. The altered genomic aberration pattern indicates that TERT promoter mutations identify a novel, highly aggressive MPM subtype presumably based on a specific malignant transformation process.