Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease.

Kamil BorkowskiTheresa L PedersenNicholas T SeyfriedJames J LahAllan I LeveyChadwick M HalesEric B DammerColette BlachGregory LouieRima Kaddurah-DaoukJohn W Newmannull null

Published in: Alzheimer's research & therapy (2021)

Previous studies report Alzheimer's disease-associated soluble epoxide hydrolase upregulation in the brain and that endocannabinoid metabolism provides an adaptive response to neuroinflammation. This study supports the involvement of P450-dependent and endocannabinoid metabolism in Alzheimer's disease. The results further suggest that combined pharmacological intervention targeting both metabolic pathways may have therapeutic benefits for Alzheimer's disease.

Keyphrases

cognitive decline
randomized controlled trial
traumatic brain injury
poor prognosis
cell proliferation
brain injury
resting state