Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer.

Chloe Camille LepageMichaela Cora Lynn PalmerAlly Catherina FarrellNicole Marie NeudorfZelda LichtensztejnMark William Nachtigal Kirk James McManus

Published in: British journal of cancer (2021)

These data identify SKP1 and CUL1 as novel CIN genes in HGSOC precursor cells that may drive early aetiological events contributing to HGSOC development.

Keyphrases

high grade
cell cycle arrest
low grade
induced apoptosis
poor prognosis
cell death
genome wide
electronic health record
big data
copy number
endoplasmic reticulum stress
pi k akt
signaling pathway
machine learning
oxidative stress
gene expression