Functional expression and pharmacological modulation of TRPM3 in human sensory neurons.
Laura VangeelMelissa BenoitYannick MironPaul E MillerKatrien De ClercqPatrick ChaltinCatherine VerfaillieJoris VriensThomas VoetsPublished in: British journal of pharmacology (2020)
These results provide the first direct evidence of functional expression of the pain receptor TRPM3 in human sensory neurons, largely mirroring the channel's properties observed in mouse sensory neurons. hSCDS neurons represent a valuable and readily accessible in vitro model to study TRPM3 regulation and pharmacology in a relevant human cellular context.