Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.

Yi-Ming ChenChun-Yu ChangHsin-Hua ChenChia-Wei HsiehKuo-Tung TangMeng-Chun YangJoung-Liang LanDer-Yuan Chen

Published in: Arthritis research & therapy (2018)

Elevated autophagy with significant correlation to inflammation suggests the involvement of autophagy in RA pathogenesis. The effectiveness of biologic therapy might be partly related to the downregulation of autophagy expression.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
rheumatoid arthritis
randomized controlled trial
poor prognosis
cell proliferation
stem cells
cell therapy
bone marrow
mesenchymal stem cells
ankylosing spondylitis
binding protein
replacement therapy