Speckle-Tracking Analysis of the Right and Left Heart after Peak Exercise in Healthy Subjects with Type 1 Diabetes: An Explorative Analysis of the AppEx Trial.
Paul ZimmermannJanis Ramon SchierbauerNiklas KopfHarald SourijNicholas S OliverFelix AbererNadine B WachsmuthOthmar MoserPublished in: Journal of cardiovascular development and disease (2023)
In eight healthy participants with Type 1 diabetes (T1D) exercise-related dynamic cardiac remodeling was analyzed by performing two-dimensional echocardiography, including deformation analysis of the left-ventricular (LV) global longitudinal strain (LV-GLS), and the deformation pattern of the left atrium (LA) and right ventricle (RV) at rest and post-peak performance on a bicycle. The feasibility echocardiographic speckle-tracking analysis was performed on eight asymptomatic participants with T1D ( n = 8, male n = 5, age: 23-65 years). The obtained echocardiographic data were compared for various echocardiographic parameters at rest and post exercise. Across our participating T1D individuals no structural echocardiographic abnormalities of concern could be revealed. All participating T1D subjects showed preserved contractile reserve of the LV and no significant diastolic dysfunction. Significant differences were found for the phasic LA contractile strain pattern at rest and post exercise ( p < 0.001), whereby the dynamic RV ( p = 0.5839 and p = 0.7419) and LV strain pattern ( p = 0.5952) did not reveal significant differences in comparison to resting conditions. This descriptive secondary outcome analysis describes preserved contractile reserve of the LV and elucidates dynamic modification of the phasic LA contractile deformation pattern in asymptomatic T1D individuals after exhaustive exercise on a bicycle.
Keyphrases
- left ventricular
- high intensity
- mitral valve
- pulmonary hypertension
- left atrial
- heart failure
- physical activity
- skeletal muscle
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- mycobacterium tuberculosis
- resistance training
- acute myocardial infarction
- ejection fraction
- aortic stenosis
- smooth muscle
- pulmonary artery
- clinical trial
- oxidative stress
- genome wide
- machine learning
- randomized controlled trial
- cross sectional
- blood pressure
- heart rate variability
- inferior vena cava
- heart rate
- pulmonary arterial hypertension
- coronary artery
- big data
- open label
- left atrial appendage
- aortic valve