Four-week inhibition of the renin-angiotensin system in spontaneously hypertensive rats results in persistently lower blood pressure with reduced kidney renin and changes in expression of relevant gene networks.

Sean G ByarsPriscilla R PrestesVara SuphapimolFumihiko TakeuchiNathan De VriesMichelle C MaierMariana MeloDavid BaldingNilesh SamaniAndrew M AllenNorihiro KatoJennifer L Wilkinson-BerkaFadi CharcharStephen B Harrap

Published in: Cardiovascular research (2024)

Early RAS inhibition in SHR resets genetic pathways and networks resulting in a legacy of reduced Ren expression and BP persisting for a minimum of 6 weeks.

Keyphrases

poor prognosis
blood pressure
genome wide
copy number
binding protein
long non coding rna
randomized controlled trial
gene expression
heart rate
clinical trial
hypertensive patients
insulin resistance
wild type
angiotensin ii
blood glucose