Aligning digital CD8+ scoring and targeted next-generation sequencing with programmed death ligand 1 expression: a pragmatic approach in early-stage squamous cell lung carcinoma.

Esther CondeAlejandra CaminoaCarolina DominguezAntonio CallesStefan WalterBarbara AnguloElena SánchezMarta AlonsoLuis JimenezLuis MadrigalFlorentino HernandoJulian Sanz-OrtegaBeatriz JimenezPilar GarridoLuis Paz-AresJavier de CastroSusana HernandezFernando López-Ríos

Published in: Histopathology (2017)

Our preliminary results support the use of digital CD8+ TILs scoring and targeted NGS alongside PD-L1 expression. The approach presented herein could help define patients with SCCs candidates to immune checkpoints inhibitors.

Keyphrases

squamous cell
early stage
cancer therapy
poor prognosis
nk cells
copy number
study protocol
randomized controlled trial
squamous cell carcinoma
gene expression
drug delivery
sentinel lymph node
rectal cancer
locally advanced
double blind