Opposite effects of dopamine on the mechanical activity of circular and longitudinal muscle of human colon.

Maria Grazia ZizzoAnnalisa BellancaAntonella Amato Rosa Serio

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

Dopamine is able to modulate contractile activity of the human colon. In the circular muscle layer, DA induces mainly muscular contraction activating non-neural D1-like receptors, coupled to PLC/IP3 pathway. In the longitudinal muscle layer, DA induces muscular relaxation acting on non-neural D2-like receptors leading to the increase in K+ conductance.

Keyphrases

skeletal muscle
endothelial cells
pluripotent stem cells
resistance training
cross sectional
signaling pathway
smooth muscle
metabolic syndrome
prefrontal cortex
high intensity