Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway.
Fan BaiYaozhong LiuTao TuBiao LiYichao XiaoYingxu MaFen QinJing XieShenghua ZhouQi Ming LiuPublished in: Lipids in health and disease (2019)
The FA metabolism in LAA is altered in the ARP group, mainly characterized by the abnormal expression of the rate-limiting enzyme. Metformin reduces lipid accumulation and promotes β-oxidation of FA in AF models partially through AMPK/PPAR-α/VLCAD pathway. Our study indicates that MET may inhibit the FA lipid metabolic remodeling in AF.
Keyphrases
- atrial fibrillation
- fatty acid
- skeletal muscle
- left atrial
- insulin resistance
- catheter ablation
- poor prognosis
- left atrial appendage
- oral anticoagulants
- heart failure
- direct oral anticoagulants
- protein kinase
- percutaneous coronary intervention
- coronary artery disease
- hydrogen peroxide
- binding protein
- left ventricular