Obesity might not alter tofacitinib drug survival in rheumatoid arthritis patients.
Esra Kayacan ErdoğanArmagan BerkanRezan Koçak UlucaköyKevser GokSerdar Can GüvenBahar Özdemir UlusoyHatice Ecem KonakÖzlem KarakaşPınar Akyüz DağlıEbru AtalarIsmail DoganYüksel MaraşAhmet OmmaOrhan KüçükşahinŞükran ErtenHakan BabaogluPublished in: Wiener klinische Wochenschrift (2024)
The findings indicate that obesity does not alter the drug survival rate for tofacitinib among RA patients. Univariate analysis reported a potentially higher drug survival rate in obese patients; however, the lack of statistical significance in multivariate analysis and the study's retrospective nature necessitate further research to validate these observations and guide personalized therapeutic strategies for this population.
Keyphrases
- obese patients
- rheumatoid arthritis
- rheumatoid arthritis patients
- bariatric surgery
- weight loss
- insulin resistance
- metabolic syndrome
- end stage renal disease
- type diabetes
- chronic kidney disease
- free survival
- newly diagnosed
- ejection fraction
- emergency department
- weight gain
- adverse drug
- roux en y gastric bypass
- peritoneal dialysis
- ulcerative colitis
- adipose tissue
- cross sectional
- gastric bypass
- systemic sclerosis
- data analysis
- interstitial lung disease
- patient reported
- idiopathic pulmonary fibrosis