The Role of Non-Coding RNAs as Prognostic Factor, Predictor of Drug Response or Resistance and Pharmacological Targets, in the Cutaneous Squamous Cell Carcinoma.
Marianna GarofoliMariateresa VolpicellaMichele GuidaLetizia PorcelliAmalia AzzaritiPublished in: Cancers (2020)
Cutaneous squamous cell carcinoma (CSCC) is the most common keratinocyte-derived skin cancer in the Caucasian population. Exposure to UV radiations (UVRs) represents the main risk carcinogenesis, causing a considerable accumulation of DNA damage in epidermal keratinocytes with an uncontrolled hyperproliferation and tumor development. The limited and rarely durable response of CSCC to the current therapeutic options has led researchers to look for new therapeutic strategies. Recently, the multi-omics approaches have contributed to the identification and prediction of the key role of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), circularRNAs (circRNAs) and long non-coding RNAs (lncRNAs) in the regulation of several cellular processes in different tumor types, including CSCC. ncRNAs can modulate transcriptional and post-transcriptional events by interacting either with each other or with DNA and proteins, such as transcription factors and RNA-binding proteins. In this review, the implication of ncRNAs in tumorigenesis and their potential role as diagnostic biomarkers and therapeutic targets in human CSCC are reported.
Keyphrases
- squamous cell carcinoma
- long non coding rna
- transcription factor
- prognostic factors
- dna damage
- skin cancer
- endothelial cells
- gene expression
- poor prognosis
- oxidative stress
- lymph node metastasis
- locally advanced
- dna repair
- single cell
- single molecule
- dna binding
- african american
- protein kinase
- electronic health record
- drug induced
- rectal cancer
- adverse drug
- pluripotent stem cells