Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis.
Bangwei LuoFuyu HanKai XuJinsong WangZongwei LiuZigang ShenJia LiYu LiuMan JiangZhi-Yuan ZhangZhi-Ren ZhangPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2017)
Experimental autoimmune neuritis (EAN) is the animal model of human acute inflammatory demyelinating polyradiculoneuropathies, an auto-immune inflammatory demyelination disease of the peripheral nervous system (PNS) and the world's leading cause of acute autoimmune neuromuscular paralysis. Here, we demonstrated that resolvin D1 (RvD1) promoted macrophage phagocytosis of apoptotic T cells in PNS, thereby upregulating transforming growth factor-β by macrophages, increased local Treg cell counts, and finally promoted inflammation resolution and disease recovery in EAN. These data highlight the crucial role of RvD1 as an important pro-resolving molecule in EAN and suggest that it has potential as a therapeutic target in human neuritis.
Keyphrases
- transforming growth factor
- oxidative stress
- drug induced
- endothelial cells
- liver failure
- multiple sclerosis
- epithelial mesenchymal transition
- single cell
- respiratory failure
- cell therapy
- cell death
- poor prognosis
- pluripotent stem cells
- palliative care
- adipose tissue
- public health
- stem cells
- single molecule
- electronic health record
- aortic dissection
- hepatitis b virus
- human health
- artificial intelligence
- peripheral blood
- mesenchymal stem cells