Prognostic significance of FAT10 expression in malignant tumors: a systematic review and meta-analysis.
Yi ZhangZheng LiXi ChenYing HuangBingwen ZouYong XuPublished in: Future oncology (London, England) (2024)
Aim: FAT10, a ubiquitin-like modifier protein, influences apoptosis, DNA damage response and tumor growth, with unclear effects on cancer prognosis. Methods: We reviewed FAT10 expression's impact on malignancy prognosis through a systematic review and meta-analysis, including studies up to September 2023 from PubMed, EMBASE and Web of Science. Results: From 18 studies involving 2513 patients, FAT10 overexpression significantly reduced overall and disease-free survival across various tumors, indicating correlations with advanced disease stage, poor differentiation, lymph node metastasis and larger tumor size. Conclusion: FAT10 's overexpression suggests a negative prognostic value in cancer, meriting further investigation. PROSPERO Registration Number: CRD42023431287.
Keyphrases
- papillary thyroid
- adipose tissue
- lymph node metastasis
- dna damage response
- poor prognosis
- free survival
- end stage renal disease
- fatty acid
- chronic kidney disease
- cell proliferation
- squamous cell carcinoma
- public health
- binding protein
- ejection fraction
- newly diagnosed
- cell death
- small molecule
- transcription factor
- squamous cell
- young adults
- long non coding rna
- dna damage
- protein protein