Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits.
Sonia Labrador VelandiaSalvatore Di LauroMaria Luz Alonso-AlonsoSoraya Tabera BartoloméGirish Kumar SrivastavaJosé Carlos PastorIván Fernández-BuenoPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2017)
MSCs are safe and well-tolerated when administered intravitreally at a dose of 15 × 106 cells/ml in pigmented rabbits. These findings enable future research to explore the intravitreal use of commercially prepared allogenic human MSCs in clinical trials of retinal diseases.
Keyphrases
- mesenchymal stem cells
- endothelial cells
- clinical trial
- diabetic retinopathy
- umbilical cord
- vascular endothelial growth factor
- induced pluripotent stem cells
- induced apoptosis
- pluripotent stem cells
- optical coherence tomography
- bone marrow
- age related macular degeneration
- randomized controlled trial
- stem cells
- cell proliferation
- oxidative stress
- cell death