Temporal dynamics of serum let-7g expression mirror the decline of residual beta-cell function in longitudinal observation of children with type 1 diabetes.

Beata MalachowskaKrystyna WykaZuzanna NowickaMarcin A BartłomiejczykWojciech MłynarskiWojciech Fendler

Published in: Pediatric diabetes (2018)

The pattern of let-7g expression change during the course of diabetes mirrors that of C-peptide levels, hinting at this microRNA's association with the residual mass of the beta cells in patients with T1DM.

Keyphrases

poor prognosis
induced apoptosis
type diabetes
cardiovascular disease
young adults
glycemic control
binding protein
cell cycle arrest
metabolic syndrome
cross sectional
endoplasmic reticulum stress
insulin resistance
adipose tissue
pi k akt