Glaucoma-Protective Human Single-Nucleotide Polymorphism in the Angpt2 Locus Increased ANGPT2 Expression and Schlemm Canal Area in Mice.
Naoki KiyotaTuncer OnayPhoebe LeeawPan LiuDilip K DebBenjamin R ThomsonAyellet V SegrèJaney L WiggsSusan E QuagginPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
The rs76020419 minor allele (T) is associated with increased levels of ANGPT2 and a larger Schlemm canal in mice. These findings suggest a potential protective mechanism in glaucoma.