Janey L Wiggs

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 27

Top Topics

Botulinum Toxin

Optical Coherence Tomography

Diabetic Retinopathy

Genome Wide Association Study

Top Venues

Nature communications

Nature genetics

Science translational medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Naoki Kiyota, Tuncer Onay, Phoebe Leeaw, Pan Liu, Dilip K Deb, Benjamin R Thomson, Ayellet V Segrè, Janey L Wiggs, Susan E Quaggin
Glaucoma-Protective Human Single-Nucleotide Polymorphism in the Angpt2 Locus Increased ANGPT2 Expression and Schlemm Canal Area in Mice. Arteriosclerosis, thrombosis, and vascular biology (2024)
Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Seyedeh Maryam Zekavat, Saman Doroodgar Jorshery, Franziska G Rauscher, Katrin Horn, Sayuri Sekimitsu, Satoshi Koyama, Trang T Nguyen, Maria C Costanzo, Dongkeun Jang, Noël P Burtt, Andreas Kühnapfel, Yusrah Shweikh, Yixuan Ye, Vineet K Raghu, Hongyu Zhao, Marzyeh Ghassemi, Tobias Elze, Ayellet V Segrè, Janey L Wiggs, Lucian Del Priore, Markus Scholz, Jay C Wang, Pradeep Natarajan, Nazlee Zebardast
Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Science translational medicine 16 (731) (2024)
Seyedeh Maryam Zekavat, Saman Doroodgar Jorshery, Franziska G Rauscher, Katrin Horn, Sayuri Sekimitsu, Satoshi Koyama, Trang T Nguyen, Maria C Costanzo, Dongkeun Jang, Noël P Burtt, Andreas Kühnapfel, Yusrah Shweikh, Yixuan Ye, Vineet K Raghu, Hongyu Zhao, Marzyeh Ghassemi, Tobias Elze, Ayellet V Segrè, Janey L Wiggs, Lucian Del Priore, Markus Scholz, Jay C Wang, Pradeep Natarajan, Nazlee Zebardast
Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Science translational medicine 16 (731) (2024)
Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Andrew R Hamel, Wenjun Yan, John M Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P Khawaja, Stuart Macgregor, null null, Rui Chen, Veronique Vitart, Joshua R Sanes, Janey L Wiggs, Ayellet V Segrè
Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma. Nature communications 15 (1) (2024)
Xikun Han, Puya Gharahkhani, Andrew R Hamel, Jue-Sheng Ong, Miguel E Renteria, Puja A Mehta, Xianjun Dong, Francesca Pasutto, Christopher J Hammond, Terri L Young, Pirro G Hysi, Andrew John Lotery, Eric Jorgensen, Helene Choquet, Michael Hauser, Jessica N Cooke Bailey, Toru Nakazawa, Masato Akiyama, Yukihiro Shiga, Zachary L Fuller, Xin Wang, Alex W Hewitt, Jamie E Craig, Louis R Pasquale, David A Mackey, Janey L Wiggs, Anthony P Khawaja, Ayellet V Segrè, null null, null null, Stuart Macgregor
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. Nature genetics (2023)
Oana A Zeleznik, Jae Hee Kang, Jessica A Lasky-Su, A Heather Eliassen, Lisa Frueh, Andrew T Chan, Bernard A Rosner, Tobias Elze, Pirro G Hysi, Anthony P Khawaja, Janey L Wiggs, Louis R Pasquale, null null
Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature communications 14 (1) (2023)
Oana A Zeleznik, Jae Hee Kang, Jessica A Lasky-Su, A Heather Eliassen, Lisa Frueh, Andrew T Chan, Bernard A Rosner, Tobias Elze, Pirro G Hysi, Anthony P Khawaja, Janey L Wiggs, Louis R Pasquale, null null
Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature communications 14 (1) (2023)
Inas F Aboobakar, Edward Ryan A Collantes, Michael A Hauser, W Daniel Stamer, Janey L Wiggs
Rare protective variants and glaucoma-relevant cell stressors modulate angiopoietin-like 7 expression. Human molecular genetics (2023)
Oana A Zeleznik, Jae Hee Kang, Jessica A Lasky-Su, A Heather Eliassen, Lisa Frueh, Andrew T Chan, Bernard A Rosner, Tobias Elze, Pirro G Hysi, Anthony P Khawaja, Janey L Wiggs, Louis R Pasquale, null null
Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature communications 14 (1) (2023)
Wendy W Liu, Tyler G Kinzy, Jessica N Cooke Bailey, Zihe Xu, Pirro G Hysi, Janey L Wiggs, null null
Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma. Scientific reports 13 (1) (2023)
Inas F Aboobakar, Janey L Wiggs
The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities-A review. Clinical & experimental ophthalmology 50 (2) (2022)
Edward Ryan A Collantes, Manuel S Delfin, Baojian Fan, Justine May R Torregosa, Christine Siguan-Bell, Nilo Vincent de Guzman Florcruz, Jose Maria D Martinez, Barbara Joy Masna-Hidalgo, Vincent Paul T Guzman, Jewel Faith Anotado-Flores, Faye D Levina, Sophia Raine C Hernandez, Anthony A Collantes, Michael Carreon Sibulo, Shisong Rong, Janey L Wiggs
EFEMP1 rare variants cause familial juvenile-onset open-angle glaucoma. Human mutation 43 (2) (2021)
Puya Gharahkhani, Eric Jorgensen, Pirro G Hysi, Anthony P Khawaja, Sarah Pendergrass, Xikun Han, Jue-Sheng Ong, Alex W Hewitt, Ayellet V Segrè, John M Rouhana, Andrew R Hamel, Robert P Igo, Helene Choquet, Ayub Qassim, Navya Shilpa Josyula, Jessica N Cooke Bailey, Pieter W M Bonnemaijer, Adriana I Iglesias, Owen M Siggs, Terri L Young, Veronique Vitart, Alberta A H J Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B Melles, K Saidas Nair, Robert N Luben, Mark J Simcoe, Nishani Amersinghe, Angela Jane Cree, Rene Hohn, Alicia Poplawski, Li Jia Chen, Shi Song Rong, Tin Aung, Eranga Nishanthie Vithana, null null, null null, null null, null null, null null, null null, null null, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K Lupton, Nicholas G Martin, Adeyinka Ashaye, Olusola Oluyinka Olawoye, Susan Eileen Isabella Williams, Stephen Akafo, Michelle Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J Foster, Peng Tee Khaw, James E Morgan, Nicholas G Strouthidis, Peter Kraft, Jae Hee Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew John Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L Haines, Christopher J Hammond, Louis R Pasquale, Caroline C W Klaver, Michael Hauser, Chiea Chuen Khor, David A Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E Craig, Stuart Macgregor, Janey L Wiggs
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature communications 12 (1) (2021)
Hannah Currant, Pirro G Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter W M Bonnemaijer, Anne Senabouth, Alex W Hewitt, null null, null null, Denize Atan, Tin Aung, Jason Charng, Helene Choquet, Jamie Craig, Peng T Khaw, Caroline C W Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej S Daniszewski, Joseph E Powell, Alice Pébay, Mark J Simcoe, Alberta A H J Thiadens, Cornelia M Van Duijn, Seyhan Yazar, Eric Jorgensen, Stuart Macgregor, Christopher J Hammond, David A Mackey, Janey L Wiggs, Paul J Foster, Praveen J Patel, Ewan Birney, Anthony P Khawaja
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. PLoS genetics 17 (5) (2021)
Seyedeh Maryam Zekavat, Vineet K Raghu, Mark Trinder, Yixuan Ye, Satoshi Koyama, Michael C Honigberg, Zhi Yu, Akhil Pampana, Sarah M Urbut, Sara Haidermota, Declan P O'Regan, Hongyu Zhao, Patrick T Ellinor, Ayellet V Segrè, Tobias Elze, Janey L Wiggs, James Martone, Ron A Adelman, Nazlee Zebardast, Lucian Del Priore, Jay C Wang, Pradeep Natarajan
Deep Learning of the Retina Enables Phenome- and Genome-wide Analyses of the Microvasculature. Circulation (2021)
Jamie E Craig, Xikun Han, Ayub Qassim, Mark M Hassall, Jessica N Cooke Bailey, Tyler G Kinzy, Anthony P Khawaja, Jiyuan An, Henry Marshall, Puya Gharahkhani, Robert P Igo, Stuart L Graham, Paul R Healey, Jue-Sheng Ong, Tiger Zhou, Owen M Siggs, Matthew H Law, Emmanuelle Souzeau, Bronwyn Ridge, Pirro G Hysi, Kathryn P Burdon, Richard A Mills, John Landers, Jonathan B Ruddle, Ashish Agar, Anna Galanopoulos, Andrew J R White, Colin Eric Willoughby, Nicholas H Andrew, Stephen Best, Andrea L Vincent, Ivan Goldberg, Graham L Radford-Smith, Nicholas G Martin, Grant W Montgomery, Veronique Vitart, Rene Hoehn, Robert Wojciechowski, Jost Bruno Jonas, Tin Aung, Louis R Pasquale, Angela Jane Cree, Sobha Sivaprasad, Neeru A Vallabh, null null, null null, Ananth C Viswanathan, Francesca Pasutto, Jonathan L Haines, Caroline C W Klaver, Cornelia M van Duijn, Robert J Casson, Paul J Foster, Peng Tee Khaw, Christopher J Hammond, David A Mackey, Paul Mitchell, Andrew John Lotery, Janey L Wiggs, Alex W Hewitt, Stuart Macgregor
Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nature genetics 52 (2) (2020)
Eric D Gaier, Inderneel Sahai, Janey L Wiggs, Brian McGeeney, Jodi Hoffman, Crandall E Peeler
Novel homozygous OPA3 mutation in an Afghani family with 3-methylglutaconic aciduria type III and optic atrophy. Ophthalmic genetics 40 (6) (2020)
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, null null, Pieter W M Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost Bruno Jonas, Irene Schmidtmann, Thibaud Boutin, Jae Hee Kang, Sionne E M Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, null null, null null, André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline C W Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart Macgregor
Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nature communications 10 (1) (2019)
Pieter W M Bonnemaijer, Elisabeth M van Leeuwen, Adriana I Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P Khawaja, Mark J Simcoe, René Höhn, Angela J Cree, Rob P Igo, null null, null null, null null, Aslihan Gerhold-Ay, Stefan Nickels, James F Wilson, Caroline Hayward, Thibaud S Boutin, Ozren Polašek, Tin Aung, Chiea Chuen Khor, Najaf Amin, Andrew John Lotery, Janey L Wiggs, Ching-Yu Cheng, Pirro G Hysi, Christopher J Hammond, Alberta A H J Thiadens, Stuart Macgregor, Caroline C W Klaver, Cornelia M van Duijn
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters. Communications biology 2 (2019)
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, null null, Pieter W M Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Emmanuelle Souzeau, Sandra E Staffieri, Jost Bruno Jonas, Irene Schmidtmann, Thibaud Boutin, Jae Hee Kang, Sionne E M Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, null null, null null, André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline C W Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart Macgregor
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nature communications 9 (1) (2018)
Anthony P Khawaja, Jessica N Cooke Bailey, Nicholas J Wareham, Robert A Scott, Mark J Simcoe, Robert P Igo, Yeunjoo E Song, Robert Wojciechowski, Ching-Yu Cheng, Peng T Khaw, Louis R Pasquale, Jonathan L Haines, Paul J Foster, Janey L Wiggs, Christopher J Hammond, Pirro G Hysi, null null, null null
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma. Nature genetics 50 (6) (2018)