Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine.

Thomas P Howard Elaine M Oberlick Matthew G Rees Taylor E Arnoff Minh-Tam PhamLisa BrenanMariana DoCarmoAndrew L Hong Guillaume Kugener Hsien-Chao Chou Yiannis DrososKaeli M MathiasPilar RamosBrinton Seashore-Ludlow Andrew O GiacomelliXiaofeng WangBurgess B FreemanKaley BlankenshipLauren HoffmannHong L TivPrafulla C GokhaleCory M JohannessenElizabeth A StewartStuart L SchreiberWilliam C Hahn Charles W M Roberts

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Rhabdoid tumor cell lines and xenografts are highly sensitive to HHT, at least partially due to their low expression of BCL2L1. HHT may have therapeutic potential against rhabdoid tumors.

Keyphrases

poor prognosis
binding protein
protein protein
amino acid
small molecule
molecularly imprinted
mass spectrometry