Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic Bone Metastases: A Multicenter, Randomized Phase II Clinical Trial.
Erin F GillespieJoanna C YangNoah J MathisCatherine B MarineCharlie WhiteZhigang ZhangChristopher A BarkerRupesh R KotechaAlyson McIntoshMax VaynrubMeredith K BartelsteinAaron P MitchellDavid M GuttmannDivya YerramilliDaniel S HigginsonYoshida J YamadaZachary A KohutekSimon N PowellChiaojung Jillian TsaiJonathan T YangPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Radiation delivered prophylactically to asymptomatic, high-risk bone metastases reduced SRE and hospitalizations. We also observed an improvement in OS with prophylactic radiation, although a confirmatory phase III trial is warranted.