Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective.
Vahideh OveissiMahboobe RamRoodabeh BahramsoltaniFarnaz EbrahimiRoja RahimiRozita NaseriTarun BelwalHari Prasad DevkotaZahra AbbasabadiMohammad Hussein FarzaeiPublished in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2019)
There are currently limited clinical evidence on medicinal plants for CIPN which shows the necessity of future mechanistic studies, as well as well-designed clinical trial for further confirmation of the safety and efficacy of herbal medicines in CIPN. Graphical abstract Schematic mechanisms of medicinal plants to prevent chemotherapy-induced neuropathy: NO: nitric oxide, TNF: tumor necrosis factor, PG: prostaglandin, NF-ĸB: nuclear factor kappa B, LPO: lipid peroxidation, ROS: reactive oxygen species, COX: cyclooxygenase, IL: interleukin, ERK: extracellular signal-related kinase, X: inhibition, ↓: induction.
Keyphrases
- chemotherapy induced
- nuclear factor
- reactive oxygen species
- toll like receptor
- nitric oxide
- clinical trial
- rheumatoid arthritis
- signaling pathway
- pi k akt
- nitric oxide synthase
- dna damage
- cell death
- inflammatory response
- immune response
- oxidative stress
- randomized controlled trial
- fatty acid
- open label
- hydrogen peroxide
- lps induced