Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis.

Camus Nimmo Arturo Torres Ortiz Cedric C S Tan Juanita Pang Mislav Acman James D Millard Leonardo Montagnani Alison D GrantMax O'DonnellAlex Pym Ola Brønstad Brynildsrud Vegard Eldholm Louis Grandjean Xavier Didelot Francois Balloux Lucy van Dorp

Published in: Genome medicine (2024)

The presence of a pre-existing reservoir of Mtb strains carrying bedaquiline RAVs prior to its clinical use augments the need for rapid drug susceptibility testing and individualised regimen selection to safeguard the use of bedaquiline in TB care and control.

Keyphrases

mycobacterium tuberculosis
drug resistant
multidrug resistant
loop mediated isothermal amplification
pulmonary tuberculosis
healthcare
escherichia coli
palliative care
water quality
copy number
quality improvement
pain management
emergency department
affordable care act
dna methylation
electronic health record