Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis.
Ahmed AbdelhakLorenzo BarbaMichele RomoliPascal BenkertFrancesco ConversiLucio D'AnnaRuturaj R MasvekarBibiana BielekovaMercedes PrudencioLeonard PetrucelliJames F MeschiaYoung ErbenRoberto FurlanRebecca De LorenzoAlessandra MandelliRaoul SutterLisa HertVarenka EppleDamiano MarastoniJohann SellnerPetra SteinackerAnne Hege AamodtLars HeggelundAnne Margarita Dyrhol-RiiseJohan VirhammarDavid FällmarElham RostamiEva KumlienKaj BlennowHenrik ZetterbergHayrettin TumaniSimona SaccoAri J GreenMarkus OttoJens KuhleRaffaele OrnelloMatteo FoschiMarkus OttoPublished in: Journal of neurology (2023)
Blood NfL levels were elevated in the acute phase of COVID-19 patients without major CNS manifestations and associated with clinical severity and poor outcome. The marker might ameliorate the performance of prognostic multivariable algorithms in COVID-19.