Higher doses of methotrexate associated with discontinuation of oral glucocorticoids after initiation of biological DMARDs: A retrospective observational study based on data from a Japanese multicenter registry study.

Mochihito Suzuki Toshihisa Kojima Nobunori Takahashi Shuji AsaiKenya TerabeAtsushi KanekoYuji HiranoMasahiro HanabayashiTakeshi OguchiHideki TakagiYasuhide KanayamaYuichiro YabeKoji FunahashiTakayoshi FujibayashiSeiji TsuboiTakayasu ItoYutaka YoshiokaHisato IshikawaYasumori SobueTsuyoshi NishiumeYutaka YokotaNaoki Ishiguro

Published in: Modern rheumatology (2021)

Our findings suggest that glucocorticoids may be discontinued after initiating bDMARDs. Moreover, higher MTX doses (>8 mg/week) at the time of bDMARD initiation were associated with glucocorticoid discontinuation among patients treated with bDMARDs.

Keyphrases

high dose
electronic health record
randomized controlled trial
cross sectional
big data
machine learning
rheumatoid arthritis
low dose
study protocol