Cross-Sectional Brain-Predicted Age Differences in Community-Dwelling Middle-Aged and Older Adults with High Impact Knee Pain.
Alisa J JohnsonTaylor BuchananChavier Laffitte NodarsePedro A Valdes-HernandezZhiguang HuoJames H ColeThomas W BufordRoger B FillingimYenisel Cruz-AlmeidaPublished in: Journal of pain research (2022)
Our findings suggest that high impact chronic knee pain is associated with an older appearing brain on MRI. Future studies are needed to determine the impact of pain-related interference and pain management on somatosensory processing and brain aging biomarkers for high-risk populations and effective intervention strategies.
Keyphrases
- pain management
- chronic pain
- community dwelling
- resting state
- white matter
- total knee arthroplasty
- cross sectional
- neuropathic pain
- physical activity
- functional connectivity
- magnetic resonance imaging
- randomized controlled trial
- cerebral ischemia
- knee osteoarthritis
- computed tomography
- multiple sclerosis
- spinal cord
- contrast enhanced
- spinal cord injury
- current status
- transcranial direct current stimulation
- diffusion weighted imaging
- drug induced
- postoperative pain