A Novel Probiotic Combination Ameliorates Crohn's Disease-Like Ileitis by Increasing Short-Chain Fatty Acid Production and Modulating Essential Adaptive Immune Pathways.
Luca Di MartinoAbdullah OsmeMahmoud GhannoumFabio CominelliPublished in: Inflammatory bowel diseases (2023)
Our data provide experimental proof for a beneficial effect of the designed probiotic formulation on the severity of CD-like ileitis in the SAMP mouse model, involving both alteration of intestinal genetic pathways and microbial rearrangements. Thus, we propose that this novel probiotic mixture should be further tested as an adjuvant therapy in the treatment of biofilm-associated disorders such as CD, in which it has been proven that polymicrobial imbalance plays a critical role in dysbiosis and gut inflammation.
Keyphrases
- mouse model
- bacillus subtilis
- fatty acid
- lactic acid
- pseudomonas aeruginosa
- oxidative stress
- staphylococcus aureus
- drug delivery
- nk cells
- microbial community
- candida albicans
- electronic health record
- signaling pathway
- escherichia coli
- biofilm formation
- copy number
- dna methylation
- deep learning
- artificial intelligence