Genetic variations in relation to bleeding and pharmacodynamics of dabigatran in Chinese patients with nonvalvular atrial fibrillation: A nationwide multicentre prospective cohort study.
Qian XiangQiufen XieZhiyan LiuGuangyan MuHanxu ZhangShuang ZhouZhe WangZining WangYatong ZhangZinan ZhaoDongdong YuanLiping GuoNa WangJing XiangHongtao SongJianjun SunJie JiangYi Min CuiPublished in: Clinical and translational medicine (2022)
Genetic variations indeed affected bleeding and PD in Chinese patients with NVAF treated with dabigatran. The functions of these suggestive genes and SNPs might further be explored and verified in more in vivo and in vitro investigations.
Keyphrases
- atrial fibrillation
- genome wide
- oral anticoagulants
- left atrial
- catheter ablation
- left atrial appendage
- direct oral anticoagulants
- dna methylation
- heart failure
- copy number
- percutaneous coronary intervention
- cross sectional
- clinical trial
- study protocol
- randomized controlled trial
- double blind
- genome wide identification