Effect of Early Versus Delayed Tracheostomy Strategy on Functional Outcome of Patients With Severe Traumatic Brain Injury: A Target Trial Emulation.

Vassilis G GiannakoulisGeorgios PsychogiosChristina RoutsiIoanna DimopoulouIlias I Siempos

Published in: Critical care explorations (2024)

In a target trial emulation, early as opposed to delayed tracheostomy strategy was not associated with differences in 6-month functional outcome following severe TBI. Considering the limitations of target trial emulations, delaying tracheostomy through a "watchful waiting" approach may be appropriate.

Keyphrases

severe traumatic brain injury
phase iii
study protocol
phase ii
clinical trial
mechanical ventilation
traumatic brain injury
randomized controlled trial
open label
early onset
intensive care unit
placebo controlled
mild traumatic brain injury