Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection.

Jeremy RatcliffDung NguyenMatthew FishJennifer RynneAislinn JenningsSarah WilliamsFarah Al-BeidhDavid BonsallAmy EvansTanya GolubchikAnthony C GordonAbigail LamikanraPat TsangNick A CicconeUllrich LeuscherWendy SlackEmma LaingPaul R MounceySheba ZiyengeMarta OliveiraRutger PloegKathryn M RowanManu Shankar-HariDavid J RobertsDavid K MenonLise EstcourtPeter SimmondsHeli Harvalanull null

Published in: The Journal of infectious diseases (2021)

High viral loads in seropositive B.1.1.7-infected subjects and resistance to seroconversion indicate less effective clearance by innate and adaptive immune responses. SARS-CoV-2 strain, viral loads, and antibody status define subgroups for analysis of treatment efficacy.

Keyphrases

sars cov
immune response
respiratory syndrome coronavirus
dendritic cells
antiretroviral therapy
hiv infected
combination therapy
cross sectional