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Synthesis and biological profile of substituted hexahydrofuro[3,4-b]furans, a novel class of bicyclic acyl-acyl carrier protein (ACP) thioesterase inhibitors.

Hartmut AhrensDavid M BarberGuido BojackBirgit Bollenbach-WahlLuke ChurchmanRahel GetachewHendrik HelmkeSabine HohmannBernd LaberGudrun LangeShaun ReesAnna M ReingruberDirk SchmutzlerJens Frackenpohl
Published in: Pest management science (2024)
The present work covers a series of novel herbicidal lead structures that possess a hexahydrofuro[3,4-b]furan scaffold as a structural key feature, carrying ortho-substituted aryloxy side chains. Based on an optimized synthetic approach a broad structure-activity relationship (SAR) study was carried out. The new compounds emerging from our modeling-inspired structural variations show good acyl-ACP thioesterase inhibition in line with promising initial herbicidal activity. Glasshouse trials showed that the hexahydrofuro[3,4-b]furans outlined herein display good control of cold and warm season grass-weed species in pre-emergence application. Remarkably, some of the novel acyl-ACP thioesterase-inhibitors also showed promising efficacy against warm season weeds that are difficult to control. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Keyphrases
  • fatty acid
  • structure activity relationship
  • molecular docking
  • public health
  • machine learning
  • high resolution
  • deep learning
  • systematic review
  • randomized controlled trial
  • protein protein
  • genetic diversity