Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition.

Masum RahmanIan OlsonMoustafa MansourLucas P Carlstrom Rujapope SutiwisesakRehan SaberKarishma RajaniArthur E WarringtonAdam HowardMark SchroederSisi ChenPaul A DeckerEliot F SananikoneYi ZhuTamar TchkoniaIan F ParneySandeep BurmaDesmond A BrownMoses RodriguezJann N Sarkaria James L Kirkland Terry C Burns

Published in: Molecular cancer research : MCR (2022)

These findings imply that molecularly heterogeneous GBM lines share selective senescence-induced BCL-XL dependency increase the significance and translational relevance of the senolytic therapy for latent glioma.

Keyphrases

induced apoptosis
high glucose
cell cycle arrest
climate change
endothelial cells
diabetic rats
dna damage
oxidative stress
endoplasmic reticulum stress
drug induced
signaling pathway
stress induced
cell death