Association between Genetic Variants of CELSR2-PSRC1-SORT1 and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.
Rosa Giannina Castillo-AvilaThelma Beatriz González-CastroCarlos Alfonso Tovilla-ZárateJosé Jaime Martínez-MagañaMaría Lilia López-NarváezIsela Esther Juárez-RojopPedro Iván Arias-VázquezVerónica Marusa Borgonio-CuadraNonanzit Pérez-HernándezJosé-Manuel Rodríguez-PérezPublished in: Journal of cardiovascular development and disease (2023)
A cluster of three genes CELSR2 , PSRC1 , and SORT1 has been associated with cardiovascular diseases. Thus, the aim of this study was (i) to perform a systematic review and updated meta-analysis of the association of three polymorphisms (rs646776, rs599839, and rs464218) of this cluster with cardiovascular diseases, and (ii) to explore by PheWAS signals of the three SNPs in cardiovascular diseases and to evaluate the effect of rs599839 with tissue expression by in silico tools. Three electronic databases were searched to identify eligible studies. The meta-analysis showed that the rs599839 (allelic OR 1.19, 95% CI 1.13-1.26, dominant OR 1.22, 95% CI 1.06-1.39, recessive OR 1.23, 95% CI 1.15-1.32), rs646776 (allelic OR 1.46, 95% CI 1.17-1.82) polymorphisms showed an increased risk for cardiovascular diseases. PheWas analysis showed associations with coronary artery disease and total cholesterol. Our results suggest a possible involvement of the CELSR2-PSRC1-SORT1 cluster variants in the risk association of cardiovascular diseases, particularly coronary artery disease.
Keyphrases
- cardiovascular disease
- coronary artery disease
- cardiovascular events
- systematic review
- cardiovascular risk factors
- type diabetes
- percutaneous coronary intervention
- genome wide
- poor prognosis
- heart failure
- dna methylation
- machine learning
- long non coding rna
- big data
- randomized controlled trial
- atrial fibrillation
- molecular docking
- muscular dystrophy
- aortic stenosis