Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression.
Abdulla WatadHannah RoweTobias RussellQiao ZhouLisa K AndersonAlmas KhanRobert DunsmuirPeter LoughenburyVishal BorseAbhay RaoPeter A MillnerNicola Luigi BragazziHoward AmitalRichard CuhtbertMiriam WittmannKassem SharifTony KennaMatthew A BrownDarren J NewtonCharlie BridgewoodDennis G McGonaglePublished in: Annals of the rheumatic diseases (2020)
Healthy human entheseal CD4+ and CD8+ T cells exhibit regulatory characteristics and are predicted to exhibit antiviral reactivity with CD8+ T cells expressing higher levels of transcripts suggestive of tissue residency. Inducible IL-17A and TNF production can be robustly inhibited in vitro.