Prognostic value of the miRNA-27a and PPAR/RXRα signaling axis in patients with thyroid carcinoma.
Eman Ali ToraihManal S FawzyAbdelrahman Ibrahim AbushoukSameerah ShaheenYahya Hasan HobaniAbdulmohsen M AlruweteiOmniah A MansouriEmad KandilDahlia I BadranPublished in: Epigenomics (2020)
The authors aimed to evaluate the prognostic value of miRNA-27a (miR-27a), peroxisome proliferator-activated receptor alpha/gamma (PPARα/γ) and retinoid X receptor alpha (RXRα) tissue expression in patients with thyroid carcinoma. The expression levels were quantified in 174 archived thyroid specimens using real-time quantitative PCR. Downregulation of miR-27a was associated with lymph node stage and multifocality. PPARα expression was associated with histopathological type, tumor size and lymph node invasion. Moreover, RXRα expression was lower in patients who underwent total/subtotal thyroidectomy or received radioactive iodine treatment. Patients with upregulated miR-27a and downregulated RXRα showed a higher frequency of advanced lymph node stage and relapse by cluster analysis. Both miR-27a and PPARα/RXRα showed association with different poor prognostic indices in thyroid cancer patients.
Keyphrases
- lymph node
- poor prognosis
- long non coding rna
- cell proliferation
- long noncoding rna
- binding protein
- neoadjuvant chemotherapy
- insulin resistance
- end stage renal disease
- chronic kidney disease
- ejection fraction
- fatty acid
- signaling pathway
- sentinel lymph node
- magnetic resonance imaging
- magnetic resonance
- computed tomography
- skeletal muscle
- locally advanced
- patient reported
- lymph node metastasis
- papillary thyroid