Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial.

Tim M J EwoldtAlan AbdullaWim J R RietdijkAnouk E MullerBrenda C M de WinterNicole G M HunfeldIlse M PurmerPeter van VlietEvert-Jan WilsJasper HaringmanAnnelies DraismaTom A RijpstraAttila KarakusDiederik GommersHenrik EndemanBirgit C P Koch

Published in: Intensive care medicine (2022)

We could not show a beneficial effect of MIPD of beta-lactam antibiotics and ciprofloxacin on ICU LOS in critically ill patients. Our data highlight the need to identify other approaches to dose optimisation.

Keyphrases

clinical trial
double blind
pseudomonas aeruginosa
study protocol
open label
phase ii
gram negative
intensive care unit
electronic health record
placebo controlled
phase iii
randomized controlled trial
big data
cystic fibrosis
multidrug resistant
cross sectional
deep learning