Comparison of gene disruption induced by cytosine base editing-mediated iSTOP with CRISPR/Cas9-mediated frameshift.

Lu DangGuanglei LiXinjie WangShisheng HuangYu ZhangYuanxin MiaoLisi ZengShu-Zhong Cui Xing-Xu Huang

Published in: Cell proliferation (2020)

Our results reveal the differences between the two gene knockout strategies and provide useful information for choosing the appropriate gene disruption strategy.

Keyphrases

crispr cas
genome wide
genome editing
copy number
genome wide identification
dna methylation
transcription factor
health information