Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer.

Simona Lombardi Aaron R Goldman Hsin-Yao Tang Andrew V Kossenkov Heng Liu Wei Zhou Meenhard Herlyn Jianhuang Lin Rugang Zhang

Published in: Cancer research communications (2023)

CARM1 reprograms fatty acid metabolism transcriptionally to support ovarian cancer growth by producing monounsaturated fatty acids, supporting SCD1 inhibition as a rational strategy for treating CARM1-expressing ovarian cancer.

Keyphrases

fatty acid
signaling pathway
cancer therapy