Targeted mutagenesis of ∆5 and ∆6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar).
Yang JinAlex K DatsomorRolf E OlsenJon Olav VikJacob S TorgersenRolf B EdvardsenAnna WargeliusPer WingeFabian GrammesPublished in: BMC genomics (2020)
CRISPR-Cas9 can efficiently mutate multiple fads2 genes simultaneously in salmon. The results of the present study have provided new information on the transcriptional regulations of lipid metabolism genes after reduction of LC-HUFA synthesis pathways in salmon.