Quercetin-loaded solid lipid nanoparticles exhibit antitumor activity and suppress the proliferation of triple-negative MDA-MB 231 breast cancer cells: implications for invasive breast cancer treatment.
Mahdi HatamiMaryam KouchakAlireza KheirollahLayasadat KhorsandiMojtaba RashidiPublished in: Molecular biology reports (2023)
This study showcases quercetin-solid lipid nanoparticles (QC-SLN) as a promising therapy for triple-negative breast cancer. The optimized QC-SLN formulation improved physicochemical properties and sustained quercetin release, resulting in reduced cell viability, colony formation, angiogenesis, and increased apoptosis in the MDA-MB231 cell line. These effects were driven by modulating Bax and Bcl-2 expression, activating caspases 3 and 9, and poly (ADP-ribose) polymerase (PARP). Further in vivo studies are needed to confirm QC-SLN's efficacy and safety.
Keyphrases
- breast cancer cells
- signaling pathway
- cell cycle arrest
- drug delivery
- sentinel lymph node
- poor prognosis
- oxidative stress
- cell death
- pi k akt
- fatty acid
- endoplasmic reticulum stress
- dna damage
- endothelial cells
- induced apoptosis
- wound healing
- cancer therapy
- early stage
- cell proliferation
- case control
- binding protein
- combination therapy
- walled carbon nanotubes
- young adults
- long non coding rna
- replacement therapy